The Rams and the Bills meet at SoFi Stadium on Tuesday 13 October (1:15pm NZDT). Our Rams vs Bills prediction covers both sides and finishes with our tips.
The highlight of Week 5 comes on Monday Night Football when the Rams host the Bills. Buffalo look a quality bet getting a field goal. Home favourites with a points differential of seven or fewer cover at just 38.8%. Josh Allen is 23-16-1 against the number as an outsider. The Rams are 3-9-1 against the spread off a win when trailing in the fourth quarter. Sean McVay is 0-4 against the spread when Scott Novak is officiating. Buffalo are very good value in this one. Khalil Shakir has not scored a touchdown this season, but he has six of the 14 red zone touches among Buffalo’s receivers, so a touchdown is due. Puka Nacua had nine catches in his return from injury last week, and he had at least eight catches in five of his last seven games last season. Kyren Williams has 21 catches in four games this season with 16 catches coming across the last two weeks.
Tips
- Best: Buffalo +3 @ $1.96
- Next: Buffalo Win @ $2.40
- First Touchdown Scorer: Khalil Shakir @ $19.00
- Anytime Touchdown Scorer: Khalil Shakir @ $3.50
- SGM: Khalil Shakir TD/Puka Nacua 8+ Receptions/Kyren Williams 4+ Receptions @ $14.93
Rams vs Bills Odds & Popular Betting Markets
Here’s a quick look at the current odds and popular betting markets for the Rams vs Bills matchup.
*odds are correct at the time of publishing and are subject to change
| Team | Odds | |
|---|---|---|
| Buffalo Bills (3) | 1.98 | Bet Now |
| Los Angeles Rams (-3) | 1.80 | Bet Now |
NFL odds correct as of 11/10/2026 and subject to change. Event scheduled to start at 13/10/2026 1:15pm NZDT.
NFL odds correct as of 11/10/2026 and subject to change. Event scheduled to start at 13/10/2026 1:15pm NZDT.