Buffalo Bills and New England Patriots meet at Highmark Stadium in Week 4 of the 2026 NFL season this Monday. Check out our preview and tips below.
There has been no more disappointing team to start the season than the New England Patriots, who have opened the season 1-2 after a stunning Super Bowl run last season. Drake Maye has thrown six picks and just a single touchdown. The Pats are averaging just 12 points per game. The Patriots though are better than what we have seen and this is a prime bounceback spot for them. Underdogs off scoring six or fewer are 40-25-1 against the spread while teams off a loss of 20-plus cover at 54%. Mike Vrabel is 30-18-2 against the spread as an underdog of at least three while Drake Maye has covered eight of 10 division games. The Pats have won and covered five straight off a loss while the Bills have covered just five of 20 at home against the Pats. New England are the best play of the week. Mack Hollins is a big price for a player who has unquestionably been Drake Maye’s top target, leading the Patriots in snaps and targets and redzone touches. He is due some positive regression in regards scoring. Josh Allen has run for at least two touchdowns in every game this season. Romeo Doubbs has caught for at least 49 yards in all three games as a Patriot.
Tips
Best: New England +7 ($1.90)
Next: New England Win ($3.60)
Touchdown: Mack Hollins ($17 First, $3.75 Anytime)
SGM: Mack Hollins TD/Josh Allen TD/Romeo Doubs Over 40.5 Rec Yards ($12.79)
Buffalo Bills vs New England Patriots Odds & Popular Betting Markets
Here’s a quick look at the current odds and popular betting markets for the Buffalo Bills vs New England Patriots matchup.
*odds are correct at the time of publishing and are subject to change